{"id":1966,"date":"2025-06-27T09:15:28","date_gmt":"2025-06-27T09:15:28","guid":{"rendered":"https:\/\/phanbontunhien.io.vn\/index.php\/2025\/06\/27\/2716-kham-pha-cac-lieu-phap-te-bao-mien-dich-nk-t-va-vaccine-dc-dot-pha-moi-trong-y-hoc-ung-thu-hien-dai\/"},"modified":"2025-06-27T09:15:28","modified_gmt":"2025-06-27T09:15:28","slug":"2716-kham-pha-cac-lieu-phap-te-bao-mien-dich-nk-t-va-vaccine-dc-dot-pha-moi-trong-y-hoc-ung-thu-hien-dai","status":"publish","type":"post","link":"https:\/\/phanbontunhien.io.vn\/index.php\/2025\/06\/27\/2716-kham-pha-cac-lieu-phap-te-bao-mien-dich-nk-t-va-vaccine-dc-dot-pha-moi-trong-y-hoc-ung-thu-hien-dai\/","title":{"rendered":"Kh\u00e1m ph\u00e1 c\u00e1c li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch NK, T v\u00e0 vaccine DC: \u0110\u1ed9t ph\u00e1 m\u1edbi trong y h\u1ecdc ung th\u01b0 hi\u1ec7n \u0111\u1ea1i"},"content":{"rendered":"

Gi\u1edbi thi\u1ec7u ng\u1eafn:<\/strong> B\u00e0i vi\u1ebft n\u00e0y s\u1ebd gi\u00fap b\u1ea1n hi\u1ec3u r\u00f5 c\u00e1ch ho\u1ea1t \u0111\u1ed9ng, l\u1ee3i \u00edch v\u00e0 \u1ee9ng d\u1ee5ng c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o nh\u01b0 NK, CAR\u2011T\/TCR\u2011T v\u00e0 vaccine t\u1ebf b\u00e0o DC. B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y theo m\u00f4 h\u00ecnh SPIN \u2013 gi\u00fap ng\u01b0\u1eddi \u0111\u1ecdc nh\u1eadn di\u1ec7n r\u00f5 t\u00ecnh hu\u1ed1ng, v\u1ea5n \u0111\u1ec1, h\u1ec7 qu\u1ea3 v\u00e0 nhu c\u1ea7u th\u1ef1c s\u1ef1 khi t\u00ecm hi\u1ec3u c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/p>\n

<\/p>\n

Kh\u00e1m ph\u00e1 Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch SETAVN<\/a><\/p>\n

\ud83e\uddec S \u2013 Situation (T\u00ecnh hu\u1ed1ng hi\u1ec7n t\u1ea1i):<\/strong> Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c quan t\u00e2m<\/h3>\n

Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, c\u00e1c c\u1ee5m t\u1eeb nh\u01b0:<\/p>\n

    \n
  1. <\/span>\u201cTr\u1ecb ung th\u01b0 b\u1eb1ng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch\u201d<\/li>\n
  2. <\/span>\u201cC\u00e1ch ho\u1ea1t \u0111\u1ed9ng c\u1ee7a vaccine t\u1ebf b\u00e0o DC\u201d<\/li>\n
  3. <\/span>\u201cCAR\u2011T c\u00f3 th\u1ef1c s\u1ef1 hi\u1ec7u qu\u1ea3?\u201d<\/li>\n<\/ol>\n

    …\u0111ang \u0111\u01b0\u1ee3c t\u00ecm ki\u1ebfm r\u1ed9ng r\u00e3i. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y m\u1ed1i quan t\u00e2m ng\u00e0y c\u00e0ng l\u1edbn t\u1eeb c\u1ed9ng \u0111\u1ed3ng b\u1ec7nh nh\u00e2n v\u00e0 ng\u01b0\u1eddi th\u00e2n v\u1ec1 c\u00e1c li\u1ec7u ph\u00e1p nh\u01b0:<\/p>\n

      \n
    1. <\/span>Li\u1ec7u ph\u00e1p NK \u2013 ti\u00eau di\u1ec7t ung th\u01b0 b\u1eb1ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh<\/li>\n
    2. <\/span>CAR\u2011T, TCR\u2011T \u2013 ch\u1ec9nh s\u1eeda gene t\u1ebf b\u00e0o T<\/li>\n
    3. <\/span>Li\u1ec7u ph\u00e1p hu\u1ea5n luy\u1ec7n h\u1ec7 mi\u1ec5n d\u1ecbch<\/li>\n<\/ol>\n

      \u26a0\ufe0f P \u2013 Problem (V\u1ea5n \u0111\u1ec1):<\/strong> Hi\u1ec3u nh\u1ea7m gi\u1eefa k\u1ef3 v\u1ecdng v\u00e0 th\u1ef1c t\u1ebf<\/h3>\n

      D\u00f9 th\u00f4ng tin tr\u00e0n lan, nh\u01b0ng nhi\u1ec1u ng\u01b0\u1eddi v\u1eabn:<\/p>\n

        \n
      1. <\/span>Tin r\u1eb1ng NK thay th\u1ebf \u0111\u01b0\u1ee3c h\u00f3a tr\u1ecb<\/li>\n
      2. <\/span>Cho r\u1eb1ng CAR\u2011T \u00e1p d\u1ee5ng cho t\u1ea5t c\u1ea3 ung th\u01b0<\/li>\n
      3. <\/span>So s\u00e1nh vaccine DC v\u1edbi vaccine ti\u00eam ng\u1eeba th\u01b0\u1eddng<\/li>\n<\/ol>\n

        Vi\u1ec7c thi\u1ebfu th\u00f4ng tin chu\u1ea9n y khoa c\u00f3 th\u1ec3 khi\u1ebfn ng\u01b0\u1eddi b\u1ec7nh:<\/p>\n

          \n
        1. <\/span>L\u00e3ng ph\u00ed ti\u1ec1n b\u1ea1c<\/li>\n
        2. <\/span>Ch\u1eadm tr\u1ec5 \u0111i\u1ec1u tr\u1ecb ch\u00ednh th\u1ed1ng<\/li>\n
        3. <\/span>M\u1ea5t ni\u1ec1m tin v\u00e0o y h\u1ecdc<\/li>\n<\/ol>\n

          \ud83d\udcc9 I \u2013 Implication (H\u1ec7 qu\u1ea3):<\/strong> \u0110i\u1ec1u g\u00ec x\u1ea3y ra n\u1ebfu ti\u1ebfp c\u1eadn sai ph\u01b0\u01a1ng ph\u00e1p?<\/h3>\n

          N\u1ebfu ng\u01b0\u1eddi b\u1ec7nh:<\/p>\n

            \n
          1. <\/span>T\u1ef1 \u00fd d\u1eebng h\u00f3a tr\u1ecb<\/li>\n
          2. <\/span>\u00c1p d\u1ee5ng sai giai \u0111o\u1ea1n b\u1ec7nh<\/li>\n
          3. <\/span>Nghe theo l\u1eddi truy\u1ec1n mi\u1ec7ng kh\u00f4ng ki\u1ec3m ch\u1ee9ng<\/li>\n<\/ol>\n

            Th\u00ec h\u1eadu qu\u1ea3 c\u00f3 th\u1ec3 l\u00e0:<\/p>\n

              \n
            1. <\/span>Gi\u1ea3m c\u01a1 h\u1ed9i s\u1ed1ng s\u00f3t<\/li>\n
            2. <\/span>T\u00e0i ch\u00ednh ki\u1ec7t qu\u1ec7<\/li>\n
            3. <\/span>Kh\u00f3 quay l\u1ea1i \u0111i\u1ec1u tr\u1ecb \u0111\u00fang ph\u00e1c \u0111\u1ed3<\/li>\n<\/ol>\n

              \u2705 N \u2013 Need (Nhu c\u1ea7u):<\/strong> Th\u00f4ng tin y khoa chu\u1ea9n, r\u00f5 r\u00e0ng v\u00e0 \u0111\u00e1ng tin c\u1eady<\/h3>\n

              Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n:<\/p>\n

                \n
              1. <\/span>Hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf t\u1eebng li\u1ec7u ph\u00e1p<\/li>\n
              2. <\/span>Bi\u1ebft ai ph\u00f9 h\u1ee3p v\u1edbi ph\u01b0\u01a1ng ph\u00e1p n\u00e0o<\/li>\n
              3. <\/span>Tr\u00e1nh b\u1ecb d\u1eabn d\u1eaft b\u1edfi qu\u1ea3ng c\u00e1o<\/li>\n<\/ol>\n

                SETA Vi\u1ec7t Nam<\/strong> ra \u0111\u1eddi v\u1edbi m\u1ee5c ti\u00eau:<\/p>\n

                  \n
                1. <\/span>Chia s\u1ebb th\u00f4ng tin y h\u1ecdc chu\u1ea9n<\/li>\n
                2. <\/span>Gi\u1ea3i th\u00edch d\u1ec5 hi\u1ec3u c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi<\/li>\n
                3. <\/span>\u0110\u1ed3ng h\u00e0nh c\u00f9ng b\u1ec7nh nh\u00e2n trong h\u00e0nh tr\u00ecnh \u0111i\u1ec1u tr\u1ecb<\/li>\n<\/ol>\n

                  \ud83d\udd2c \u0110i s\u00e2u t\u1eebng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch n\u1ed5i b\u1eadt<\/strong><\/h3>\n

                  \ud83d\udd39 T\u1ebf b\u00e0o s\u00e1t th\u1ee7 NK<\/a><\/strong><\/h4>\n
                    \n
                  1. <\/span>L\u00e0 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch b\u1ea9m sinh, ti\u00eau di\u1ec7t t\u1ebf b\u00e0o l\u1ea1 m\u00e0 kh\u00f4ng c\u1ea7n MHC<\/strong>.<\/li>\n
                  2. <\/span>C\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng IL\u20112, IL\u201115<\/strong> ho\u1eb7c t\u1eeb d\u00f2ng NK\u201192<\/strong>.<\/li>\n
                  3. <\/span>\u1ee8ng d\u1ee5ng: \u0111i\u1ec1u tr\u1ecb th\u1eed nghi\u1ec7m<\/strong> ung th\u01b0 ph\u1ed5i, gan, v\u00fa<\/strong>.<\/li>\n
                  4. <\/span>\u01afu \u0111i\u1ec3m: \u00edt t\u00e1c d\u1ee5ng ph\u1ee5<\/strong>, h\u00e0nh \u0111\u1ed9ng nhanh<\/strong>.<\/li>\n<\/ol>\n

                    \ud83d\udd39 Li\u1ec7u ph\u00e1p ch\u1ec9nh s\u1eeda gene t\u1ebf b\u00e0o T<\/a><\/strong><\/h4>\n
                      \n
                    1. <\/span>CAR\u2011T<\/strong>: Nh\u1eafm \u0111\u1ebfn kh\u00e1ng nguy\u00ean nh\u01b0 CD19, hi\u1ec7u qu\u1ea3 cao \u1edf ung th\u01b0 m\u00e1u<\/strong>.<\/li>\n
                    2. <\/span>TCR\u2011T<\/strong>: Nh\u1eadn di\u1ec7n kh\u00e1ng nguy\u00ean n\u1ed9i b\u00e0o, m\u1edf r\u1ed9ng ph\u1ea1m vi \u0111i\u1ec1u tr\u1ecb.<\/li>\n
                    3. <\/span>H\u1ea1n ch\u1ebf: chi ph\u00ed cao<\/strong>, d\u1ec5 g\u00e2y CRS<\/strong>, ch\u01b0a hi\u1ec7u qu\u1ea3 v\u1edbi kh\u1ed1i u r\u1eafn<\/strong>.<\/li>\n<\/ol>\n

                      \ud83d\udd39 Li\u1ec7u ph\u00e1p ti\u00eam ch\u1ee7ng mi\u1ec5n d\u1ecbch DC<\/a><\/strong><\/h4>\n
                        \n
                      1. <\/span>D\u00f9ng t\u1ebf b\u00e0o DC \u0111\u1ec3 hu\u1ea5n luy\u1ec7n h\u1ec7 mi\u1ec5n d\u1ecbch<\/strong> nh\u1eadn di\u1ec7n t\u1ebf b\u00e0o ung th\u01b0.<\/li>\n
                      2. <\/span>Hi\u1ec7u qu\u1ea3: t\u1ea1o mi\u1ec5n d\u1ecbch ghi nh\u1edb<\/strong>, k\u00e9o d\u00e0i th\u1eddi gian s\u1ed1ng.<\/li>\n
                      3. <\/span>\u0110ang th\u1eed nghi\u1ec7m \u1edf ung th\u01b0 gan, ph\u1ed5i, tuy\u1ebfn ti\u1ec1n li\u1ec7t<\/strong>.<\/li>\n<\/ol>\n

                        \ud83d\udce2 SETA mang \u0111\u1ebfn g\u00ec cho c\u1ed9ng \u0111\u1ed3ng?<\/h3>\n
                          \n
                        1. <\/span>Th\u00f4ng tin trung l\u1eadp, r\u00f5 r\u00e0ng<\/li>\n
                        2. <\/span>\u0110\u1ed9i ng\u0169 y t\u1ebf, bi\u00ean t\u1eadp chuy\u00ean s\u00e2u<\/li>\n
                        3. <\/span>Li\u00ean t\u1ee5c c\u1eadp nh\u1eadt c\u00f4ng ngh\u1ec7 m\u1edbi<\/li>\n<\/ol>\n

                          \ud83e\udde0 K\u1ebft lu\u1eadn<\/strong><\/h3>\n

                          Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o NK, T v\u00e0 vaccine DC l\u00e0 h\u01b0\u1edbng \u0111i \u0111\u1ea7y ti\u1ec1m n\u0103ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 t\u0103ng c\u01b0\u1eddng h\u1ec7 mi\u1ec5n d\u1ecbch. Tuy nhi\u00ean, s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 hi\u1ec3u bi\u1ebft l\u00e0 \u0111i\u1ec1u c\u1ea7n thi\u1ebft.<\/p>\n

                          SETA Vi\u1ec7t Nam<\/a><\/strong> s\u1ebd l\u00e0 ng\u01b0\u1eddi b\u1ea1n y khoa \u0111\u00e1ng tin c\u1eady, gi\u00fap b\u1ea1n ti\u1ebfp c\u1eadn y h\u1ecdc hi\u1ec7n \u0111\u1ea1i m\u1ed9t c\u00e1ch \u0111\u00fang \u0111\u1eafn.<\/p>\n","protected":false},"excerpt":{"rendered":"

                          Gi\u1edbi thi\u1ec7u ng\u1eafn: B\u00e0i vi\u1ebft n\u00e0y s\u1ebd gi\u00fap b\u1ea1n hi\u1ec3u r\u00f5 c\u00e1ch ho\u1ea1t \u0111\u1ed9ng, l\u1ee3i \u00edch v\u00e0 \u1ee9ng d\u1ee5ng c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o nh\u01b0 NK, CAR\u2011T\/TCR\u2011T v\u00e0 vaccine t\u1ebf b\u00e0o DC. B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y theo m\u00f4 h\u00ecnh SPIN \u2013 gi\u00fap ng\u01b0\u1eddi \u0111\u1ecdc nh\u1eadn di\u1ec7n r\u00f5 t\u00ecnh hu\u1ed1ng, v\u1ea5n \u0111\u1ec1, […]\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1966","post","type-post","status-publish","format-standard","hentry","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/posts\/1966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/comments?post=1966"}],"version-history":[{"count":0,"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/posts\/1966\/revisions"}],"wp:attachment":[{"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/media?parent=1966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/categories?post=1966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/phanbontunhien.io.vn\/index.php\/wp-json\/wp\/v2\/tags?post=1966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}